Butyl phenol toxicity pdf

Reproductive toxicity category 2 chronic aquatic toxicity category 1 hazard symbols. The information on the summary is basic information and is not intended to provide emergency response information or information on medical treatment. Jan 31, 2012 2 critical toxicity the general character of effect of ptbp is described in the occupational medical toxicological documentation of the mak value published in 1981 1. Screening assessment for the challenge 2,4,6tritert. A low concern for acute toxicity by the oral or dermal route of exposure. Quickly access for a patent airway, ensure adequate respiration and pulse. Preliminary information on manufacturing, processing. However, 2,4dimethyl6t butylphenol is unique in its toxicity to the rabbit, being as lethal by simple application to the intact skin as by the oral route of administration. Natural sources and bioactivities of 2,4ditertbutylphenol. State and local disposal regulations may differ from federal disposal regulations.

Orthosecondary butyl phenol market size, share, growth. Screening assessment cas rn 732263 substance identity for the purposes of this document, this substance will be referred to as 2,4,6tritertbutylphenol, which has been derived from the philippine inventory of chemicals and. Transportation information this product is a regulated material for domestic ground transporation, per cfr title 49. Chronic exposure or carcinogenicity in order to study the chronic toxicity of 2, 4, 6tritertbutylphenol ttbp, groups of 40 slc. Predicted data is generated using the us environmental protection agencys episuite. The capacity and selectivity of these organic solvents in each of. The phenol 2,6ditertbutyl4 nitrophenol dbnp is a contaminant found onboard submarines and is formed by the nitration of an antioxidant present in turbine lubricating oil tep 2190. However, 2,4dimethyl6 butyl4methylphenol and 3,5dimethylphenol have a lower degree of acute toxicity than phenol itself. Pdf the antioxidant 2,6ditertbutylphenol moiety attenuates pro. Wistar rats of either sex were fed diet containing 0, 30, 100, 300 or ppm of ttbp for up to 24 months. Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived. Safety data sheet according to 29cfr19101200 and ghs rev.

Contact with liquid phenol can cause severe skin burns. Extreme high moderate low section 1 chemical product and company identification product name 6tertbutyl2,4xylenol statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Dow surfactants alternatives to alkyl phenol ethoxylate. Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, gmp products, impurities and metabolites, apis for veterinary, natural compounds, adcs, stem cell molecule and chiral compounds. The capacity and selectivity of these organic solvents in each of these systems were determined from the tielines data. General description 2,6ditertbutyl4dimethylaminome thylphenol is a hindered phenolic compound that is used as an antioxidant to stabilize the lubricant oils. A role for tyrosinaserelated protein 1 in 4tertbutylphenolinduced toxicity in melanocytes. This colorless solid alkylated phenol and its derivatives are used industrially as uv stabilizers and antioxidants for hydrocarbonbased products ranging from petrochemicals to plastics. Dow surfactants alternatives to alkyl phenol ethoxylate ape. Biotransformation of 4secbutylphenol by grampositive bacteria of the genera mycobacterium and nocardia including modifications on the alkyl chain and the hydroxyl group.

Dow surfactants alternatives to alkyl phenol ethoxylate ape, apeo surfactants. Phenols, such as 4tertbutyl phenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl oh group in their structure. Biotransformation of 4secbutylphenol by grampositive bacteria of the genera mycobacterium and nocardia including. Use this link for bookmarking this species for future reference. Research corridor new comprehensive study on orthosecondary butyl phenol market offers indepth analysis on industry trends, market size, competitive analysis and market forecast 2020 to 2027. The greatest potential source of exposure to phenol is in the occupational setting, where phenol is used in manufacturing processes. Phenols and cresols are much weaker as acids than common carboxylic acids phenol has pka 9. The product, 4tertbutylphenol 4tbp, is employed in the production of a variety of phenolformaldehyde resins which. Section 1 chemical product and company identification product name 2,6ditertbutylphenol statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Dispose released into the air, this material is exp ected to have a halflife between 1 and 10 days.

Decomposition of dinitro selectives, like many other herbicides, causes considerable stimulation of crop growth. Phenol is an aromatic organic compound with the molecular formula c 6 h 5 oh. Comparative toxicity of certain tbutyl substituted cresols. Comparison of aquatic toxicity data between 4tertbutylphenol and. Phytotoxic activity of the allelochemical, 2,4ditertbutylphenol on.

Extraction of phenol from industrial water using different solvents sally n. Phenol, 3tertbutyl permanent link for this species. Extraction of phenol from industrial water using different. Phenol is a colorless or white solid when it is pure. Phenol lc50 inhalation, rat 316 mgm34hr ld50 skin, rat 669 mgkg ld50 oral, mouse 270 mgkg water no information available phenol is listed by the iarc as group 3, unclassifiable. Ac160120000, ac160120025, ac160120050, ac160125000 synonyms. However, 2,4dimethyl6t butyl phenol is unique in its toxicity to the rabbit, being as lethal by simple application to the intact skin as by the oral route of administration. Section 1 identification of the substancemixture and of the companyundertaking trade name ptertbutylphenol. Toxicity of ammonium dinitroosecbutyl phenolate in. Central drug house p ltd 728 vardaan house new delhi2 india. December 23, 2014 the dow chemical company page 5 of 6 references 1 nbutyl acetate technical data sheet, the dow chemical company, form no. Functional uses natural substances and extractives. Phenols, such as 2,4dimethyl6tertbutyl phenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl oh group in their structure.

Review of testicular toxicity of dinitrophenolic compounds, 2sec butyl 4,6dinitrophenol, 4,6dinitroocresol and 2,4dinitrophenol. Pdf of full article, cite this article abstract when used as selective or general contact sprays, dinitro osec butyl phenol compounds decompose too rapidly to create any problem of residual toxicity. Kurian and sugunan 2006 and huang et al 2006 have reported requirement of strong acid sites for the formation of 2,4dtbp in the alkylation of phenol with tert butyl alcohol. Chemicalprotective clothing butyl rubber gloves and aprons is recommended because phenol liquid and vapor can be quickly absorbed through the skin and may contribute to systemic toxicity. However, dialkylation depends only on the availability of tert butyl cation for the monoalkylated products. Sj8925000 section 3 hazards identification emergency overview irritant. Phenol is so inexpensive that it attracts many smallscale uses. Product safety summary 2,4ditertbutylphenol 2,4dtbp this product safety summary is intended to provide a general overview of the chemical substance. Preliminary information on manufacturing, processing, distribution, use and disposal. Review of testicular toxicity of dinitrophenolic compounds, 2secbutyl4,6dinitrophenol, 4,6dinitroocresol and 2,4dinitrophenol. Waterphenolchloroform, waterphenolisobutyl acetate, waterphenolbutanol, waterphenolethyl methyl keton and waterphenoltoluene, were determined at 303 k and atmospheric pressure. Screening assessment cas rn 732263 synopsis pursuant to section 74 of the canadian environmental protection act, 1999 cepa 1999, the ministers of the environment and of health have conducted a screening assessment on phenol, 2,4,6tris1,1dimethylethyl 2,4,6tritertbutylphenol, chemical abstracts service registry number 732263. Toxicity of 2,6ditertbutyl4nitrophenol dbnp request pdf. Identification of the substancepreparation and of the companyundertaking product name phenol unid no un1671 synonyms phenol molecular weight 94.

Woluwe alma court lenneke marelaan, 8 b1932 ststevenswoluwe belgium 2010. Phenol,2,4di1,1dimethylethyl company identification. Phenol butanol, water phenol ethyl methyl keton and water phenol toluene, were determined at 303 k and atmospheric pressure. Comparative toxicity of certain tbutyl substituted cresols and xylenols. A toxicological profile for phenol, draft for public comment was released in october 2006. When used as selective or general contact sprays, dinitroosecbutyl phenol compounds decompose too rapidly to create any problem of residual toxicity. Summary of how the substance meets the criteria set out in article 57e of reach persistency. Phenols, such as 2,4dimethyl6tert butyl phenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl oh group in their structure. Illustrative of its usefulness, it prevents gumming in aviation fuels. Contact allergy to 2hydroxy5tert butyl benzylalcohol and 2,6bishydroxymethyl4tertbutylphenol, components of a phenolic resin used in marking pens.

However, 2,4dimethyl6 butyl 4methylphenol and 3,5dimethylphenol have a lower degree of acute toxicity than phenol itself. Comparative toxicity of certain tbutyl substituted. Orlrat ld50 320 mg kg1, ivnmus ld50 60 mg kg1, sknrbt ld50 5560 mg kg1, orlgpg ld50 600 mg kg1 ou chemical safety data no longer updated more details safety. Material safety data sheet toxin and toxintarget database. The global orthosecondary butyl phenol market size is expected to register a significant cagr during the forecast period 2020 to 2027. In silico prediction of toxicity of phenols to tetrahymena pyriformis by using genetic algorithm and decision treebased modeling approach. Phenol, 4methyl, reaction products with dicyclopentadiene and isobutylene reaction product of 4methylphenol with 2methylpropene and tricyclo5. Mildly acidic, it requires careful handling because it can cause chemical burns phenol was first extracted from coal tar, but today is produced on a large scale about 7 billion. Screening tertiary butylphenols, methylphenols, and longchain.

Longterm exposure to phenol derivatives can cause skin. Butyl phenol produces patchy depigmentation which resembles or is the same as the well. It is the active ingredient in some oral analgesics such as chloraseptic spray, tcp and carmex, commonly used to temporarily treat pharyngitis. There is no warranty of accuracy or completeness of any information contained herein. Pdf the allelochemical 2,4ditertbutylphenol 2,4dtbp is one of the natural. Packaging 1 kg in poly bottle 250 g in poly bottle application antioxidant. This edition supersedes any previously released draft or final profile. The information on the summary is basic information and is not intended to provide emergency response. Sigmaaldrich material safety data sheet product name 4tert. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. Registrant supplier registered updated confidential afton chemical s.